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FOXP1 Polyclonal Antibody
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FIGURE: 1 / 14
FOXP1 Antibody (PA5-52006) in ICC/IF
Immunofluorescence analysis of FOXP1 was performed using 70% confluent log phase Hep G2 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with FOXP1 Polyclonal Antibody (Product # PA5-52006) at 1:200 in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32790), (1... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-52006
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FOXP1. Recombinant protein control fragment (Product #RP-100703).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QMQQLQQQHL LSLQRQGLLT IQPGQPALPL QPLAQGMIPT ELQQLWKEVT SAHTAEETTG NNHSSLDLTT TCVSSSAPSK TSLIMNPHAS TNGQLSVHTP KRESLSHEEH PHSHPLYGHG VCKWPGCEAV CEDFQSFLKH LNS
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 97%.
Target Information
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ23741; Fork head related protein like B; fork head-related protein like B; Forkhead box protein P1 (FOXP1); forkhead-related transcription factor 1; FOXP1; Foxp1b; Foxp1c; Glutamine rich factor 1; glutamine-rich factor 1; mac-1-regulated forkhead; MGC12942; MGC88572; MGC99551; unnamed protein product
Gene Aliases: 12CC4; 3110052D19Rik; 4932443N09Rik; hFKH1B; HSPC215; MFH; QRF1
UniProt ID: (Human) Q9H334, (Mouse) P58462, (Rat) Q498D1
Entrez Gene ID: (Human) 27086, (Mouse) 108655, (Rat) 297480
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
identical protein binding
sequence-specific DNA binding
androgen receptor binding
sequence-specific double-stranded DNA binding
transcription regulatory region sequence-specific DNA binding
transcription cofactor binding
DNA binding
chromatin binding
negative regulation of transcription from RNA polymerase II promoter
negative regulation of B cell apoptotic process
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
regulation of gene expression
positive regulation of endothelial cell migration
negative regulation of gene expression
striatum development
osteoclast differentiation
forebrain development
response to lipopolysaccharide
regulation of interleukin-1 beta production
regulation of interleukin-12 production
regulation of tumor necrosis factor production
positive regulation of interleukin-21 production
response to testosterone
osteoclast development
macrophage activation
monocyte activation
endothelial cell activation
regulation of monocyte differentiation
negative regulation of transcription, DNA-templated
animal organ development
positive regulation of smooth muscle cell proliferation
regulation of inflammatory response
positive regulation of B cell receptor signaling pathway
negative regulation of androgen receptor signaling pathway
negative regulation of cell growth involved in cardiac muscle cell development
T follicular helper cell differentiation
cellular response to tumor necrosis factor
regulation of defense response to bacterium
regulation of macrophage colony-stimulating factor production
positive regulation of hydrogen peroxide-mediated programmed cell death
regulation of endothelial tube morphogenesis
regulation of chemokine (C-X-C motif) ligand 2 production
positive regulation of mesenchymal cell proliferation
pre-B cell differentiation
positive regulation of immunoglobulin production
heart development
skeletal muscle tissue development
motor neuron axon guidance
ventral spinal cord development
lung development
immunoglobulin V(D)J recombination
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
smooth muscle tissue development
positive regulation of epithelial cell proliferation
cardiac muscle cell differentiation
regulation of cardiac muscle cell proliferation
regulation of androgen receptor signaling pathway
lung secretory cell differentiation
regulation of lung goblet cell differentiation
negative regulation of lung goblet cell differentiation
positive regulation of TORC1 signaling
cellular response to ionomycin
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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