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Invitrogen
MT3 Polyclonal Antibody
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Product Details
PA5-52042
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MT3. Recombinant protein control fragment (Product #RP-102274).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MDPETCPCPS GGSCTCADSC KCEGCKCTSC KKSCCSCCPA ECEKCAKDCV CKGGEAAEAE AEKCS
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 83%.
Target Information
Metallothionein (MT) is a sulfhydryl- and cysteine-rich protein found in micro-organisms, plants and all invertebrate and vertebrate animals. Metallothioneins are a group of ubiquitous low-molecular-weight proteins that have functional roles in cell growth, repair and differentiation. Metallothionein are implicated primarily in metal ion detoxification as they are essential for the protection of cells against the toxicity of cadmium, mercury and copper. Metallothioneins are known to be broadly expressed in heart, liver, kidney, breast and testis tissue. Metallothionein 3, also known as MT-3 or GIFB (growth inhibitory factor), is a 68 amino acid protein that belongs to the type 1 family and Metallothionein superfamily. While highly expressed in astrocytes of the normal human brain, Metallothionein 3 expression is reduced in the brains of patients with Alzheimer disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GIF; GIFB; Growth inhibitory factor; metallothionein 3 (growth inhibitory factor (neurotrophic)); Metallothionein-3; Metallothionein-III; MT-3; MT-III
Gene Aliases: GIF; GIFB; GRIF; MT3; ZnMT3
UniProt ID: (Human) P25713
Entrez Gene ID: (Human) 4504
response to hypoxia
positive regulation of protein phosphorylation
energy reserve metabolic process
zinc II ion transport
cellular zinc ion homeostasis
response to oxidative stress
detoxification of copper ion
positive regulation of gene expression
negative regulation of neuron projection development
removal of superoxide radicals
cellular cation homeostasis
negative regulation of cell growth
negative regulation of axon extension
positive regulation of vascular endothelial growth factor receptor signaling pathway
regulation of response to food
activation of protein kinase B activity
leptin-mediated signaling pathway
cellular response to oxidative stress
cellular response to reactive oxygen species
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
positive regulation of transcription, DNA-templated
negative regulation of neurogenesis
protein stabilization
negative regulation of oxidoreductase activity
positive regulation of ERK1 and ERK2 cascade
cellular response to cadmium ion
cellular response to copper ion
cellular response to zinc ion
cellular response to hypoxia
detoxification of cadmium ion
cellular detoxification
negative regulation of hydrogen peroxide catabolic process
positive regulation of oxygen metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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