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Invitrogen
FOXJ1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-52189
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FOXJ1. Recombinant protein control fragment (Product #RP-102512).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PREKDEPGKG GFWRIDPQYA ERLLSGAFKK RRLPPVHIHP AFARQAAQEP SAVPRAGPLT VNTEAQQLLR EFEEATGEAG WGAGEGRLGH KRKQPLPKRV AKVPRPPSTL LPTPEEQGEL EPLKG
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 29%.
Target Information
Forkhead-box J1 (FOXJ1) is a 421-amino acid transcription factor that suppresses T cell activity and spontaneous autoimmunity, through the repression of NF B activity. FOXJ1 also inhibits the humoral immune response in B cells. FOXJ1 deficiency in B cells results in spontaneous and accentuated germinal center formation and is implicated in the development of pathogenic autoantibodies and accentuated responses to immunizations. Abnormal expression of FOXJ1 may be associated with autoimmune diseases and/or other inflammatory diseases. FOXJ1 is also required for cilia formation and left-right axis determination because it increases calpastatin expression, a protein necessary for the ability of basal bodies to anchor to the apical cytoskeleton. FOXJ1 expression may function as an early marker of epithelial cell differentiation, recovery, and function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: fork head homologue 4; forkhead transcription factor HFH-4; forkhead-like 13; forkhead-related protein FKHL13; hepatocyte nuclear factor 3 forkhead homolog 4; MGC35202
Gene Aliases: CILD43; FKHL13; HFH-4; HFH4
UniProt ID: (Human) Q92949
Entrez Gene ID: (Human) 2302
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
central tolerance induction
negative regulation of germinal center formation
positive regulation of central B cell tolerance induction
negative regulation of humoral immune response mediated by circulating immunoglobulin
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
humoral immune response
spermatogenesis
determination of left/right symmetry
pattern specification process
brain development
protein localization
actin cytoskeleton organization
ciliary basal body organization
negative regulation of interleukin-6 production
negative regulation of T cell differentiation in thymus
axoneme assembly
establishment of apical/basal cell polarity
metanephric part of ureteric bud development
negative regulation of T cell proliferation
motile cilium assembly
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of B cell activation
leukocyte migration
cilium morphogenesis
lung epithelium development
epithelium development
glomerular parietal epithelial cell development
negative regulation of NIK/NF-kappaB signaling
positive regulation of lung ciliated cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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