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Invitrogen
TAF6 Polyclonal Antibody
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Product Details
PA5-52310
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TAF6. Recombinant protein control fragment (Product #RP-89319).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LSDIINTPLP RVPLDVCLKA HWLSIEGCQP AIPENPPPAP KEQQKAEATE PLKSAKPGQE EDGPLKGKGQ GATTADGKGK EKKAPPLLEG APLRLKPRSI HELSVEQQLY YKEITEACVG SCEAKRAEAL QSIATDPG
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
Target Information
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Four isoforms have been identified but complete transcripts have been determined for only three isoforms. One of the isoforms has been shown to preclude binding of one of the other TFIID subunits, thereby reducing transcription and initiating signals that trigger apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp781E21155; RNA polymerase II TBP-associated factor subunit E; TAF(II)70; TAF(II)80; TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa; TAFII70; TATA box binding protein (TBP)-associated factor, RNA polymerase II, E, 70/85kD; Transcription initiation factor TFIID 70 kDa subunit; Transcription initiation factor TFIID 80 kDa subunit; Transcription initiation factor TFIID subunit 6; unnamed protein product
Gene Aliases: ALYUS; MGC:8964; TAF(II)70; TAF(II)80; TAF2E; TAF6; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85
UniProt ID: (Human) P49848
Entrez Gene ID: (Human) 6878
regulation of DNA repair
DNA-templated transcription, initiation
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
apoptotic process
negative regulation of cell proliferation
mRNA transcription from RNA polymerase II promoter
positive regulation of apoptotic process
negative regulation of cell cycle
positive regulation of transcription, DNA-templated
RNA polymerase II transcriptional preinitiation complex assembly
positive regulation of transcription initiation from RNA polymerase II promoter
positive regulation of intrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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