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Invitrogen
Titin Polyclonal Antibody
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Product Details
PA5-52379
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Titin. Recombinant protein control fragment (Product #RP-89761).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GTVSTSCYLA VQVSEEFEKE TTAVTEKFTT EEKRFVESRD VVMTDTSLTE EQAGPGEPAA PYFITKPVVQ KLVEGGSVVF GCQVGGNPKP HVYWKKSGVP LTTGYRYKVS YNKQTGECKL VISMTFADDA GEYT
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 27%.
Target Information
Monoclonal Anti-Titin can be used for study of the elastic filaments within sarcomeric structures. It is also useful as a differentiation marker in the separation of rhabdomyosarcomas from other muscle tumors. By indirect immunofluorescence the antibody displays a typical striated staining pattern on frozen sections of chicken skeletal and cardiac muscle tissues. Stains the region of the A-I junction by indirect immunofluorescence. It shows a decoration line 0.05 mm from the end of the A band in electron micro-graphs. In immunoblotting using total extracts of chicken breast muscle the antibody reacts specifically with both bands of the titin doublet, and showed no reaction with nebulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2.7.11.1; autoimmune antigenic domain; Connectin; DKFZp451N061; FLJ26020; FLJ26409; FLJ32040; FLJ34413; FLJ39564; FLJ43066; Rhabdomyosarcoma antigen MU-RMS-40.14; titan; muscle filament; Titin; unnamed protein product
Gene Aliases: CMD1G; CMH9; CMPD4; CMYO5; CMYP5; EOMFC; HMERF; LGMD2J; LGMDR10; MYLK5; SALMY; TMD; TTN
UniProt ID: (Human) Q8WZ42
Entrez Gene ID: (Human) 7273
nucleotide binding
protease binding
protein kinase activity
protein serine/threonine kinase activity
protein tyrosine kinase activity
structural molecule activity
calcium ion binding
protein binding
calmodulin binding
ATP binding
cytoskeletal protein binding
structural constituent of muscle
kinase activity
transferase activity
protein kinase regulator activity
enzyme binding
protein kinase binding
telethonin binding
identical protein binding
protein homodimerization activity
actinin binding
metal ion binding
actin filament binding
muscle alpha-actinin binding
structural molecule activity conferring elasticity
protein serine kinase activity
skeletal muscle contraction
cardiac muscle hypertrophy
muscle contraction
striated muscle contraction
mitotic chromosome condensation
positive regulation of gene expression
protein kinase A signaling
muscle filament sliding
skeletal muscle thin filament assembly
skeletal muscle myosin thick filament assembly
detection of muscle stretch
sarcomere organization
sarcomerogenesis
positive regulation of protein secretion
response to calcium ion
cardiac myofibril assembly
cardiac muscle tissue morphogenesis
cardiac muscle cell development
cardiac muscle contraction
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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