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Invitrogen
SERCA3 ATPase Polyclonal Antibody
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Product Details
PA5-52397
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SERCA3 ATPase. Recombinant protein control fragment (Product #RP-88662).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SRDRKSMSVY CTPTRPHPTG QGSKMFVKGA PESVIERCSS VRVGSRTAPL TPTSREQILA KIRDWGSGSD TLRCLALATR DAPPRKEDME LDDCSKFVQY E
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 89%.
Target Information
ATP dependent calcium pumps are responsible in part for the maintenance of low cytoplasmic free calcium concentrations. The ATP pumps that reside in intracellular organelles are encoded by a family of structurally related enzymes, termed the sarcoplasmic or endoplasmic reticulum calcium ATPases (SERCA). The SERCA2 gene is subject to tissue dependent processing which is responsible for the generation of SERCA2a muscle-specific isoform expressed in type I (slow) skeletal, cardiac and smooth muscle and the SERCA2b isoform expressed in all cell types. SERCA3 has been found to co-express with SERCA2b in platelets, mast cells, lymphoid cells, and epithelial cells. Due to this pattern of expression it is referred to as the non-muscle form of SERCA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adenosine triphosphatase, calcium; ATPase, Ca(2+)-transporting, ubiquitous; ATPase, Ca++ transporting, ubiquitous; calcium ATPase; SERCA3f; Calcium pump 3; calcium-translocating P-type ATPase; sarco/endoplasmic reticulum Ca(2+)-ATPase 3-type Ca2+ pump; sarco/endoplasmic reticulum Ca2+ -ATPase; Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; SERCA3; SERCA3D; SERCA3E; SR Ca(2+)-ATPase 3; unnamed protein product
Gene Aliases: ATP2A3; SERCA3
UniProt ID: (Human) Q93084
Entrez Gene ID: (Human) 489
nucleotide binding
calcium channel regulator activity
calcium-transporting ATPase activity
protein binding
ATP binding
cysteine-type endopeptidase activator activity involved in apoptotic process
calcium ion transmembrane transporter activity
ATPase activity
calcium-dependent ATPase activity
ion channel binding
metal ion binding
ion transport
calcium ion transport
cellular calcium ion homeostasis
ion transmembrane transport
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
calcium ion transmembrane transport
transport across blood-brain barrier
calcium ion transport from cytosol to endoplasmic reticulum
regulation of cardiac conduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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