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Invitrogen
FKBP15 Polyclonal Antibody
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Product Details
PA5-52495
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FKBP15. Recombinant protein control fragment (Product #RP-89625).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KHSAGNSMLI PSMSVTMETS MIMSNIQRII QENERLKQEI LEKSNRIEEQ NDKISELIER NQRYVEQSNL MMEKRNNSLQ TATENTQARV LHAEQEKAKV TEELAAATAQ VSHLQLKMTA HQ
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 94%.
Target Information
FKBP15, also known as FKBP133, is a member of the FK506-binding protein family, a group of proteins initially identified as immunophilins, targets for the immunosupressant drugs FK506 and Rapamycin. FKBP15 is expressed in the developing nervous system and contains a domain similar to Wiskott-Aldrich syndrome protein homology region 1 (WH1) in addition to the FK506-binding protein motif. FKBP15 is distributed along the axonal shafts and partially co-localizes with F-actin in the growth cones of dorsal root ganglion neurons; overexpression of FKBP15 resulted in the number of filopodia in transfected neurons, suggesting that FKBP15 modulates growth cone behavior. FKBP15 has also been shown to associate with both microtubules and the actin filament systems and disruption of its expression by RNAi resulted in delayed transport of early endosomes in HeLa cells indicating that FKBP15 is also involved in the transport of early endosomes. At least three isoforms of FKBP15 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 133 kDa FK506-binding protein; 133 kDa FKBP; FK506 binding protein 15, 133kDa; FK506-binding protein 133kDa; FK506-binding protein 15; FKBP prolyl isomerase 15; FKBP-133; FKBP-15; protein phosphatase 1, regulatory subunit 76; unnamed protein product; WAFL; WASP and FKBP-like protein; WASP- and FKBP-like protein
Gene Aliases: FKBP133; FKBP15; KIAA0674; PPP1R76
UniProt ID: (Human) Q5T1M5
Entrez Gene ID: (Human) 23307
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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