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Invitrogen
TSKU Polyclonal Antibody
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Product Details
PA5-52523
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TSKU. Recombinant protein control fragment (Product #RP-89879).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DTAHLDLSSN RLEMVNESVL AGPGYTTLAG LDLSHNLLTS ISPTAFSRLR YLESLDLSHN GLTALPAESF TSSPLSDVNL SHNQLREVSV SAFTTHSQGR ALHVDLSHNL IHR
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 93%.
Target Information
The TSKU gene encodes Tsukushi, a member of the small leucine-rich proteoglycan (SLRP) family, playing crucial roles in cellular signaling, growth, and development. Tsukushi is characterized by its involvement in various biological processes, including immune regulation, tissue remodeling, and metabolic homeostasis. It is a hepatokine released in response to conditions like nonalcoholic fatty liver disease (NAFLD), influencing metabolic traits and contributing to conditions such as dyslipidemia and cardiovascular diseases. Tsukushi impacts energy expenditure by modulating brown fat thermogenesis, thereby affecting metabolic homeostasis and obesity-related metabolic traits. As an extracellular matrix component, Tsukushi participates in signaling pathways that regulate cell proliferation, migration, and differentiation, impacting organ development and pathophysiological processes. Its role in metabolic and inflammatory diseases presents it as a potential biomarker and therapeutic target in conditions characterized by altered metabolic and inflammatory states. Ongoing research further elucidates Tsukushi's mechanisms and interactions, contributing to our understanding of its multifunctional roles in health and disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E2-induced gene 4 protein; Early insulin-induced hepatic gene protein; EIIH; hepatic protein EIIH; leucine rich repeat containing 54; Leucine-rich repeat-containing protein 54; Tsukushi; tsukushi homolog; tsukushi small leucine rich proteoglycan homolog; tsukushin; unnamed protein product
Gene Aliases: 9530051K01Rik; E2IG4; Eiih; LRRC54; TSK; TSKU; UNQ850/PRO1788
UniProt ID: (Human) Q8WUA8, (Rat) Q6QMY6, (Mouse) Q8CBR6
Entrez Gene ID: (Human) 25987, (Rat) 308843, (Mouse) 244152
growth plate cartilage chondrocyte development
immune response
transforming growth factor beta receptor signaling pathway
nervous system development
cholesterol metabolic process
anatomical structure morphogenesis
regulation of gene expression
negative regulation of neuron projection development
corpus callosum morphogenesis
lateral ventricle development
hippocampus development
anterior commissure morphogenesis
negative regulation of Wnt signaling pathway
negative regulation of transforming growth factor beta1 production
cholesterol efflux
wound healing
cholesterol homeostasis
positive regulation of hair cycle
camera-type eye development
inner ear receptor stereocilium organization
ciliary body morphogenesis
energy homeostasis
bone growth
negative regulation of myofibroblast differentiation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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