Immunohistochemical analysis of PSMA2 in human cervix, uterine using PSMA2 Polyclonal Antibody (Product # PA5-52527) shows no positivity in squamous epithelial cells as expected.

PSMA2 Antibody in Immunohistochemistry (IHC)

Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

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PSMA2 Antibody — Antibody specificity was demonstrated by siRNA mediated knockdown of target protein. U2OS cells were transfected with, control siRNA, PSMA2 siRNA probe #1, and PSMA2 siRNA probe #2 and a decrease in signal intensity was observed in Western Blot application using Anti-PSMA2 Polyclonal Antibody (Product # PA5-52527) used at a dilution of 0.4 µg/mL. Anti-GAPDH was used as a loading control. {KD}

Immunogen image

Immunogen Image PSMA2 Polyclonal Antibody

Product Details

PA5-52527

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PSMA2. Recombinant protein control fragment (Product #RP-89896).

3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

5 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2646051

Product Specific Information

Immunogen sequence: SGAYFAWKAT AMGKNYVNGK TFLEKRYNED LELEDAIHTA ILTLKESFEG QMTEDNIEVG ICNEAGFRRL TPTEVKDYLA AIA

Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.

Target Information

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alpha-2; macropain subunit C3; multicatalytic endopeptidase complex subunit C3; OTTHUMP00000207364; OTTHUMP00000207366; proteasome (prosome, macropain) subunit, alpha type 2; proteasome (prosome, macropain) subunit, alpha type, 2; proteasome alpha 2 subunit; proteasome component C3; proteasome component C3 protein; proteasome subunit alpha 2; proteasome subunit HC3; PSMA 2; PSMA2; unnamed protein product

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Gene Aliases: HC3; Lmpc3; MU; PMSA2; PSC2

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UniProt ID: (Human) P25787, (Mouse) P49722, (Rat) P17220

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Entrez Gene ID: (Human) 5683, (Mouse) 19166, (Rat) 29669

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Function(s)

protein binding structural constituent of proteasome

Process(es)

ubiquitin-dependent protein catabolic process response to oxidative stress response to virus proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process regulation of proteasomal protein catabolic process immune system process DNA repair apoptotic process cellular response to DNA damage stimulus spermatogenesis proteasomal ubiquitin-independent protein catabolic process sperm motility positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of tumor necrosis factor production response to interferon-gamma CD8-positive, alpha-beta T cell differentiation thymic T cell selection T-helper 1 cell differentiation negative regulation of regulatory T cell differentiation meiotic cell cycle cellular response to type I interferon T-helper 17 cell differentiation CD8-positive, alpha-beta T cell homeostasis regulation of G1/S transition of mitotic cell cycle

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PSMA2 Polyclonal Antibody

PSMA2 Antibody (PA5-52527) in IHC (P)

Product Details

PA5-52527

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Amount

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

References (0)

Bioinformatics

Performance Guarantee

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