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Invitrogen
HMGCR Polyclonal Antibody
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Product Details
PA5-52547
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human HMGCR. Recombinant protein control fragment (Product #RP-102327).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MAGSIGGYNA HAANIVTAIY IACGQDAAQN VGSSNCITLM EASGPTNEDL YISCTMPSIE IGTVGGGTNL LPQQACLQML GVQGACKDNP GENARQLARI VCGTVMAGEL SLMAALAAGH LVKSHMIHNR SKINLQDLQG
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.
Target Information
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) is a key enzyme in the mevalonate pathway, which is critical for the biosynthesis of cholesterol and other isoprenoids. HMGCR catalyzes the conversion of HMG-CoA to mevalonate, a rate-limiting step in the production of cholesterol. Due to its central role in cholesterol synthesis, HMGCR is a primary target for statin drugs, which are used to lower cholesterol levels and reduce the risk of cardiovascular disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl coenzyme A reductase; 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMDH; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; hydroxymethylglutaryl-CoA reductase; MGC103269; unnamed protein product
Gene Aliases: HMGCR; LDLCQ3; LGMDR28; MYPLG
UniProt ID: (Human) P04035
Entrez Gene ID: (Human) 3156
lipid metabolic process
steroid biosynthetic process
cholesterol biosynthetic process
steroid metabolic process
cholesterol metabolic process
isoprenoid biosynthetic process
visual learning
coenzyme A metabolic process
sterol biosynthetic process
negative regulation of protein catabolic process
negative regulation of protein secretion
long-term synaptic potentiation
regulation of ERK1 and ERK2 cascade
negative regulation of beta-amyloid clearance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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