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Invitrogen
NMI Polyclonal Antibody
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Product Details
PA5-52584
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NMI. Recombinant protein control fragment (Product #RP-89342).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KINVTEIPDT LREDQMRDKL ELSFSKSRNG GGEVDRVDYD RQSGSAVITF VEIGVADKIL KKKEYPLYIN QTCHRVTVSP YTEIHLKKYQ IFSGTSKRTV LLTGMEGIQM DEEIVEDLIN IHFQRAKNGG GEVDVVKCSL GQPH
Highest antigen sequence identity to the following orthologs: Mouse - 74%, Rat - 46%.
Target Information
NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: interacts with N-myc, C-myc, Max, and other transcription factors carrying leucine zipper (Zip), helix-loop-helix (HLH) or HLH-; N-myc and STAT interactor; N-myc-interactor; Nmi; unnamed protein product
Gene Aliases: NMI
UniProt ID: (Human) Q13287
Entrez Gene ID: (Human) 9111
macrophage activation involved in immune response
immune system process
JAK-STAT cascade
negative regulation of cell proliferation
response to virus
negative regulation of type I interferon production
negative regulation of interferon-alpha production
negative regulation of interferon-beta production
toll-like receptor 4 signaling pathway
innate immune response
regulation of innate immune response
positive regulation of innate immune response
negative regulation of innate immune response
positive regulation of inflammatory response
protein K48-linked ubiquitination
negative regulation of NIK/NF-kappaB signaling
positive regulation of NIK/NF-kappaB signaling
positive regulation of protein K48-linked ubiquitination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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