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Invitrogen
ALDH1A2 Polyclonal Antibody
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FIGURE: 1 / 11
ALDH1A2 Antibody (PA5-52684) in ICC/IF
Immunofluorescence analysis of ALDH1A2 was performed using K562 and HeLa cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with ALDH1A2 Polyclonal Antibody (Product # PA5-52684) at 5µg/mL in 0.1% BSA and incubated overnight at 4 degree and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034) at a dilution of 1:20... View More
Product Details
PA5-52684
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ALDH1A2. Recombinant protein control fragment (Product #RP-89838).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VVGSPFDPTT EQGPQIDKKQ YNKILELIQS GVAEGAKLEC GGKGLGRKGF FIEPTVFSNV TDDMRIAKEE IFGPVQEILR FKTMDEVIER ANNSDFGLVA AVFTNDINKA LTVSSAMQAG TV
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
Target Information
This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Three transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AL1A2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; RALDH 2; RALDH(II); Retinal dehydrogenase 2; Retinaldehyde-specific dehydrogenase type 2; unnamed protein product
Gene Aliases: ALDH1A2; DIH4; RALDH(II); RALDH2; RALDH2-T
UniProt ID: (Human) O94788
Entrez Gene ID: (Human) 8854
blood vessel development
kidney development
liver development
retinoic acid biosynthetic process
heart morphogenesis
cellular aldehyde metabolic process
lipid metabolic process
vitamin A metabolic process
midgut development
cell proliferation
positive regulation of cell proliferation
negative regulation of cell proliferation
determination of bilateral symmetry
anterior/posterior pattern specification
proximal/distal pattern formation
positive regulation of gene expression
neural crest cell development
morphogenesis of embryonic epithelium
neural tube development
pituitary gland development
neuron differentiation
lung development
embryonic limb morphogenesis
forebrain development
hindbrain development
pancreas development
embryonic camera-type eye development
response to estradiol
response to retinoic acid
response to vitamin A
response to cytokine
embryonic forelimb morphogenesis
ureter maturation
retinol metabolic process
retinoic acid metabolic process
retinal metabolic process
9-cis-retinoic acid biosynthetic process
camera-type eye development
positive regulation of apoptotic process
retinoic acid receptor signaling pathway
embryonic digestive tract development
cardiac muscle tissue development
protein homotetramerization
face development
cellular response to retinoic acid
regulation of vascular endothelial cell proliferation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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