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Invitrogen
DTX3L Polyclonal Antibody
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Product Details
PA5-52708
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DTX3L. Recombinant protein control fragment (Product #RP-89860).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ERKPLSQQER DSCISPSEPE TKAEQKSNYF EVPLPYFEYF KYICPDKINS IEKRFGVNIE IQESSPNMVC LDFTSSRSGD LEAARESFAS EFQKNTEPLK QECVSLADSK QANKFKQELN HQFTKL
Highest antigen sequence identity to the following orthologs: Mouse - 42%, Rat - 46%.
Target Information
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-lymphoma- and BAL-associated protein; BBAP; deltex 3 like, E3 ubiquitin ligase; deltex 3-like; E3 ubiquitin-protein ligase DTX3L; Protein deltex-3-like; Rhysin-2; Rhysin2; RING-type E3 ubiquitin transferase DTX3L; unnamed protein product
Gene Aliases: BBAP; DTX3L; RNF143
UniProt ID: (Human) Q8TDB6
Entrez Gene ID: (Human) 151636
ubiquitin-protein transferase activity
enzyme inhibitor activity
protein binding
zinc ion binding
transferase activity
enzyme binding
histone binding
ubiquitin-like protein ligase binding
metal ion binding
ubiquitin protein ligase activity
STAT family protein binding
protein ADP-ribosyltransferase-substrate adaptor activity
histone ubiquitin ligase activity
histone H4K91 ubiquitin ligase activity
DNA damage checkpoint
positive regulation of defense response to virus by host
immune system process
DNA repair
double-strand break repair
chromatin organization
ubiquitin-dependent protein catabolic process
cellular response to DNA damage stimulus
Notch signaling pathway
endosome to lysosome transport
protein transport
protein ubiquitination
positive regulation of protein binding
positive regulation of chromatin binding
innate immune response
positive regulation of transcription, DNA-templated
negative regulation of ubiquitin-protein transferase activity
defense response to virus
protein autoubiquitination
protein K48-linked ubiquitination
DNA repair-dependent chromatin remodeling
positive regulation of protein localization to nucleus
positive regulation of protein localization to early endosome
positive regulation of receptor catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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