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Invitrogen
SPINK5 Polyclonal Antibody
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Product Details
PA5-52820
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SPINK5. Recombinant protein control fragment (Product #RP-89259).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QQEERARAKA KREAAKEICS EFRDQVRNGT LICTREHNPV RGPDGKMHGN KCAMCASVFK LEEEEKKNDK EEKGKVEAEK VKREAVQELC SEYRHYVRNG RLPC
Highest antigen sequence identity to the following orthologs: Mouse - 68%, Rat - 73%.
Target Information
Lympho-epithelial Kazal-type inhibitor (LEKTI) is a serine protease inhibitor which protects mucous epithelia against microbial attack and inflammation. LEKTI is a marker of epithelial differentiation and expresses strongly in the granular and uppermost spinous layers of the epidermis and differentiated layers of stratified epithelia. Defects in SPINK5, the gene encoding LEKTI, are the cause of Netherton syndrome, a severe autosomal recessive disorder characterized by atopic dermatitis, hayfever and other conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ISK5; LEKTI; Lympho-epithelial Kazal-type-related inhibitor; lymphoepithelial Kazal-type-related inhibitor; Serine protease inhibitor Kazal-type 5
Gene Aliases: LEKTI; LETKI; NETS; NS; SPINK5; VAKTI
UniProt ID: (Human) Q9NQ38
Entrez Gene ID: (Human) 11005
negative regulation of antibacterial peptide production
epidermal cell differentiation
negative regulation of angiogenesis
extracellular matrix organization
epithelial cell differentiation
hair cell differentiation
anagen
regulation of T cell differentiation
negative regulation of immune response
negative regulation of serine-type endopeptidase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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