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Invitrogen
CLSTN1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-52936
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CLSTN1. Recombinant protein control fragment (Product #RP-90471).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SHEPFSVTED YPLHPSKIET QLVVGACWQE FSGVENDNET EPVTVASAGG DLHMTQFFRG NLAGLTLRSG KLADKKVIDC LYTCKEGLDL QVLEDSGRGV QIQAHPSQLV LTLEGEDLGE LDKAMQHISY LNS
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 77%.
Target Information
CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alcadein-alpha; alzheimer-related cadherin-like protein; cadherin-related family member 12; FLJ32258; non-classical cadherin XB31alpha; unnamed protein product; X11-like binding protein 31 type alpha1
Gene Aliases: ALC-ALPHA; alcalpha1; alcalpha2; CDHR12; CST-1; CSTN1; XB31alpha
UniProt ID: (Human) O94985
Entrez Gene ID: (Human) 22883
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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