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Invitrogen
ATP7A Polyclonal Antibody
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Product Details
PA5-53003
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ATP7A. Recombinant protein control fragment (Product #RP-92226).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TETLGTCIDF QVVPGCGISC KVTNIEGLLH KNNWNIEDNN IKNASLVQID ASNEQSSTSS SMIIDAQISN ALNAQQYKVL IGNREWMIRN GLVINNDVND FMTEHERKGR TAVLVAVDDE LC
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 84%.
Target Information
ATP7A (also known as Copper-transporting ATPase 1) functions as a transmembrane copper-translocating P-type ATPase and plays a vital role in systemic copper absorption in the gut and copper reabsorption in the kidney. Polarized epithelial cells such as Madin-Darby canine kidney cells are a physiologically relevant model for systemic copper absorption and reabsorption in vivo. Although ATP7A is not detectable in most normal tissues, it is expressed in a considerable fraction of many common tumor types. Increased expression of ATP7A renders cells resistant to cisplatin and carboplatin. Mutations in the ATP7A gene result in Menkes disease, which is fatal in early childhood.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP 7A; ATP7A; ATPase, Cu++ transporting, alpha polypeptide; Copper pump 1; Copper-transporting ATPase 1; Cu++-transporting P-type ATPase; FLJ17790; MC 1; Menke; Menkes disease-associated protein; Menkes syndrome; OHS; OTTHUMP00000062077; unnamed protein product
Gene Aliases: ATP7A; DSMAX; HMNX; MC1; MK; MNK; SMAX3
UniProt ID: (Human) Q04656
Entrez Gene ID: (Human) 538
nucleotide binding
copper ion transmembrane transporter activity
copper ion binding
protein binding
ATP binding
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
superoxide dismutase copper chaperone activity
ATPase activity
cation-transporting ATPase activity
copper-dependent protein binding
copper-transporting ATPase activity
metal ion binding
P-type monovalent copper transporter activity
cuprous ion binding
blood vessel development
release of cytochrome c from mitochondria
blood vessel remodeling
regulation of oxidative phosphorylation
tryptophan metabolic process
tyrosine metabolic process
catecholamine metabolic process
ion transport
cation transport
copper ion transport
cellular copper ion homeostasis
mitochondrion organization
locomotory behavior
glycoprotein biosynthetic process
detoxification of copper ion
regulation of gene expression
copper ion import
removal of superoxide radicals
cerebellar Purkinje cell differentiation
pyramidal neuron development
central nervous system neuron development
extracellular matrix organization
collagen fibril organization
hair follicle morphogenesis
T-helper cell differentiation
epinephrine metabolic process
norepinephrine metabolic process
dopamine metabolic process
norepinephrine biosynthetic process
serotonin metabolic process
pigmentation
negative regulation of neuron apoptotic process
skin development
negative regulation of catecholamine metabolic process
ATP metabolic process
positive regulation of melanin biosynthetic process
elastic fiber assembly
lung alveolus development
neuron projection morphogenesis
dendrite morphogenesis
cartilage development
neuron apoptotic process
establishment of localization in cell
copper ion export
neuron cellular homeostasis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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