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Invitrogen
HIP1 Polyclonal Antibody
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Product Details
PA5-53068
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human HIP1. Recombinant protein control fragment (Product #RP-90751).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: NFLRASALSE HISPVVVIPA EASSPDSEPV LEKDDLMDMD ASQQNLFDNK FDDIFGSSFS SDPFNFNSQN GVNKDEKDHL IERLYREISG LKAQLENMKT ESQRVVLQLK GHVSELEADL AEQQHLRQQA ADDCEFLRAE LDELRRQRED
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.
Target Information
Huntingtin disease, a neurodegenerate disease, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a reportedly proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of Huntingtin disease. As well as playing a role in Huntingtin disease, it is likely to be involved in the recruitment of clathrin coats to lipid membranes and it may also factor in tumorigenesis by allowing the survival of precancerous and cancerous cells. Since HIP-1 expression is significantly associated with prostate and colon cancer metastasis, HIP-1 can serve as a putative prognostic factor for prostate and colon cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HIP I; HIP-1; HIP-I; hip1; Huntingtin-interacting protein 1; Huntingtin-interacting protein I
Gene Aliases: 2610109B09Rik; A930014B11Rik; E130315I21Rik; HIP-I; HIP1; ILWEQ; Kiaa4113; mKIAA4113; SHON; SHONbeta; SHONgamma
UniProt ID: (Human) O00291, (Mouse) Q8VD75
Entrez Gene ID: (Human) 3092, (Rat) 192154, (Mouse) 215114
transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
cytoskeleton organization
cell differentiation
regulation of apoptotic process
positive regulation of receptor-mediated endocytosis
clathrin coat assembly
clathrin-mediated endocytosis
apoptotic signaling pathway
endocytosis
actin cytoskeleton organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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