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Invitrogen
UGT8 Polyclonal Antibody
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Product Details
PA5-53160
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human UGT8. Recombinant protein control fragment (Product #RP-90684).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SALHERGHHT VFLLSEGRDI APSNHYSLQR YPGIFNSTTS DAFLQSKMRN IFSGRLTAIE LFDILDHYTK NCDLMVGNHA LIQGLKKEKF DLLLVDPNDM CGFVIAHLLG VKYAVFSTGL WYPAEVGAPA
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
Target Information
UGT8 (UDP-galactose-ceramide galactosyltransferase, 2-hydroxyacylsphingosine 1-beta-galactosyltransferase) is a 541 amino acid, single pass membrane protein of the UDP-glycosyltransferase family. UGT8 is believed to be primarily involved with the metabolism of sphingolipids and galactosylceramide biosynthesis. UGT8 is one of six genes whose elevated expression has been correlated with a significantly increased the risk of lung metastases in breast cancer patients. As such, UGT8 may be a significant index of tumor aggressiveness and a potential marker for the prognostic evaluation of lung metastases in breast cancer. UGT8 is ubiquitously expressed with highest levels found in central and peripheral nervous systems and is up-regulated in breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase; Ceramide UDP-galactosyltransferase; Cerebroside synthase; UDP-galactose-ceramide galactosyltransferase; unnamed protein product; uridine diphosphate glycosyltransferase 8
Gene Aliases: CGT; UGT4; UGT8
UniProt ID: (Human) Q16880
Entrez Gene ID: (Human) 7368
protein localization to paranode region of axon
lipid metabolic process
sphingolipid metabolic process
galactosylceramide biosynthetic process
glycosphingolipid biosynthetic process
cytoskeleton organization
nervous system development
central nervous system development
peripheral nervous system development
glycolipid biosynthetic process
paranodal junction assembly
response to immobilization stress
neuron projection morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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