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Invitrogen
ARID5B Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-53270
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MRF2. Recombinant protein control fragment (Product #RP-90906).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TSKYPSRDMY RESENSSFPS HRHQEKLHVN YLTSLHLQDK KSAAAEAPTD DQPTDLSLPK NPHKPTGKVL GLAHSTTGPQ ESKGISQFQV LGSQSRDCHP KACRVSPMTM SGPKKYPESL SRSGKPHHVR LENFRKME
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 24%.
Target Information
ARID5B encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipogenesis and liver development. ARID5B also plays a role in cell growth and differentiation of B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARID domain-containing protein 5B; AT-rich interactive domain 5B (MRF1-like); modulator recognition factor 2 (MRF2); MRF1-like protein; unnamed protein product
Gene Aliases: DESRT; MRF-2; MRF2
UniProt ID: (Human) Q14865
Entrez Gene ID: (Human) 84159
negative regulation of transcription from RNA polymerase II promoter
liver development
regulation of transcription from RNA polymerase II promoter
positive regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
adipose tissue development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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