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Invitrogen
PTPRZ Polyclonal Antibody
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Product Details
PA5-53280
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PTPRZ. Recombinant protein control fragment (Product #RP-89895).
Conjugate
Form
Liquid
Concentration
0.30 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LFRHLHTVSQ ILPQVTSATE SDKVPLHASL PVAGGDLLLE PSLAQYSDVL STTHAASETL EFGSESGVLY KTLMFSQVEP PSSDAMMHAR SSGPEPSYAL SDNEGSQHIF TVSYSSAIPV HDSVGVTYQG SLFSGPSHIP IPKSSLIT
Highest antigen sequence identity to the following orthologs: Mouse - 68%, Rat - 72%.
Target Information
Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: protein tyrosine phosphatase, receptor-type, Z polypeptide 1; protein tyrosine phosphatase, receptor-type, zeta polypeptide 1; Protein-tyrosine phosphatase receptor type Z polypeptide 1; Protein-tyrosine phosphatase receptor type Z polypeptide 2; R-PTP-zeta; R-PTP-zeta-2; receptor-type tyrosine phosphatase beta/zeta; Receptor-type tyrosine-protein phosphatase zeta
Gene Aliases: HPTPZ; HPTPzeta; HTPZP2; phosphacan; PTP-ZETA; PTP18; PTPRZ; PTPRZ1; PTPRZ2; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta
UniProt ID: (Human) P23471
Entrez Gene ID: (Human) 5803
hematopoietic progenitor cell differentiation
protein dephosphorylation
axonogenesis
axonal fasciculation
central nervous system development
learning or memory
negative regulation of cell proliferation
visual learning
negative regulation of cell-substrate adhesion
hippocampus development
peptidyl-tyrosine dephosphorylation
positive regulation of fibroblast proliferation
oligodendrocyte differentiation
regulation of dendrite morphogenesis
positive regulation of peptidyl-tyrosine phosphorylation
regulation of oligodendrocyte progenitor proliferation
positive regulation of dendrite development
positive regulation of Schwann cell migration
positive regulation of neuron death
negative regulation of dendrite development
positive regulation of neuron migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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