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Invitrogen
BEND3 Polyclonal Antibody
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Product Details
PA5-53659
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human BEND3. Recombinant protein control fragment (Product #RP-90911).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: CLPQLNDFFS RFWAQREMED SQPSGQVASF FEAEQVDPGH FLDNKDQEEA LSLDRSSTIA SDHVVDTQDL TEFLDEASSP GEFAVFLLHR LFPELFDHRK LGEQYSCYGD GGKQELDPQR LQIIRNYTEI YFPD
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
Target Information
Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites. Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BEN domain-containing protein 3
Gene Aliases: BEND3; KIAA1553
UniProt ID: (Human) Q5T5X7
Entrez Gene ID: (Human) 57673
negative regulation of transcription from RNA polymerase II promoter
chromatin silencing at rDNA
DNA methylation
transcription, DNA-templated
chromatin modification
histone H4-K20 trimethylation
histone H3-K9 trimethylation
histone H4 acetylation
histone H3-K4 trimethylation
histone H3-K27 trimethylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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