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Invitrogen
TTBK2 Polyclonal Antibody
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Product Details
PA5-53728
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TTBK2. Recombinant protein control fragment (Product #RP-91429).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TTEPLDVTKT QTFSVVPNQD KNNEIMKLLT VGTSEISSRD IDPHVEGQIG QVAEMQKNKI SKDDDIMSED LPGHQGDLST FLHQEGKREK ITPRNGELFH CVS
Highest antigen sequence identity to the following orthologs: Mouse - 74%, Rat - 78%.
Target Information
Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Tau-tubulin kinase 2; unnamed protein product
Gene Aliases: KIAA0847; SCA11; TTBK; TTBK2
UniProt ID: (Human) Q6IQ55
Entrez Gene ID: (Human) 146057
microtubule cytoskeleton organization
negative regulation of microtubule depolymerization
signal transduction
smoothened signaling pathway
protein localization
regulation of smoothened signaling pathway
peptidyl-serine phosphorylation
cerebellum development
cerebellar granular layer development
neural tube development
cerebellar granule cell precursor tangential migration
cell projection organization
regulation of cell migration
forebrain development
protein localization to organelle
embryonic digit morphogenesis
cilium morphogenesis
negative regulation of protein localization to microtubule
positive regulation of nonmotile primary cilium assembly
negative regulation of cellular protein localization
embryonic brain development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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