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Invitrogen

SMARCB1 Polyclonal Antibody

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SMARCB1 Polyclonal Antibody

Product Details

PA5-53764

Applications
Tested Dilution
Publications

Western Blot (WB)

0.04-0.4 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SMARCB1. Recombinant protein control fragment (Product #RP-92347).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Amount

10 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2647611

Product Specific Information

Immunogen sequence: SVTLLKASEV EEILDGNDEK YKAVSISTEP PTYLREQKAK RNSQWVPTLP NSSHHLDAVP CSTTINRNRM GRDKKRTFPL CFDDHDPAVI HENASQPE

Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

Target Information

The SWI-SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. Brm (also designated SNF2alpha) and Brg-1 (also designated SNF2beta) are the ATPase subunits of the mammalian SWI-SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, also designated SNF5), BAF155 (also designated SRG3) and BAF170 are thought to comprise the functional core of the SWI-SNF complex. Addition of Ini1, BAF155 and BAF170 to Brg-1 appears to increase remodeling activity. Other complex subunits are thought to play regulatory roles. hSNF2L and hSNF2H both appear to be homologs of Drosophila ISWI, a Brm related ATPase that is present in chromatin remodeling complexes other than SWI/SNF, including the NURF (nucleosome remodeling factor).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BAF47; BRG1-associated factor 47; BRG1-associated factor 47 (BAF47); hSNF5; Ini1; Ini1b; INI1D; INI1E; INI1F; Integrase interactor 1 protein; malignant rhabdoid tumor suppressor; mSNF5; protein phosphatase 1, regulatory subunit 144; SMARCB1; SNF5 homolog; Sucrose nonfermenting yeast homolog like 1; sucrose nonfermenting, yeast, homolog-like 1; SWI/SNF related matrix-associated actin dependent regulator of chromatin, subfamily b, member 1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; SWI/SNF-related matrix-associated protein; SWI10; Transcription factor TYE4; Transcription regulatory protein SNF5; TYE4; unnamed protein product

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Gene Aliases: AU020204; BAF47; CSS3; hSNFS; INI-1; INI1; MRD15; PPP1R144; RDT; RTPS1; Sfh1p; SMARCB1; SNF5; SNF5/INI1; SNF5L1; Snr1; SWNTS1

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UniProt ID: (Human) Q12824, (Mouse) Q9Z0H3

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Entrez Gene ID: (Human) 6598, (Mouse) 20587, (Rat) 361825

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Function(s)
RNA polymerase I CORE element sequence-specific DNA binding p53 binding DNA binding transcription coactivator activity protein binding Tat protein binding nucleosomal DNA binding identical protein binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding DNA metabolism protein
Process(es)
RNA polymerase I preinitiation complex assembly blastocyst development blastocyst hatching chromatin organization nucleosome disassembly chromatin remodeling regulation of transcription from RNA polymerase II promoter nervous system development negative regulation of cell proliferation DNA integration regulation of mitotic metaphase/anaphase transition single stranded viral RNA replication via double stranded DNA intermediate positive regulation by host of viral transcription positive regulation of T cell differentiation positive regulation of cell differentiation positive regulation of myoblast differentiation positive regulation of gene expression, epigenetic positive regulation of transcription from RNA polymerase II promoter regulation of G0 to G1 transition hepatocyte differentiation positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter positive regulation of stem cell population maintenance positive regulation of glucose mediated signaling pathway regulation of G1/S transition of mitotic cell cycle positive regulation of double-strand break repair regulation of nucleotide-excision repair DNA repair transcription, DNA-templated regulation of transcription, DNA-templated cell cycle chromatin modification cell differentiation ATP-dependent chromatin remodeling mitotic cell cycle phase transition positive regulation of sequence-specific DNA binding transcription factor activity biological_process
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