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Invitrogen
PDE1B Polyclonal Antibody
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Product Details
PA5-53817
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PDE1B. Recombinant protein control fragment (Product #RP-92038).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TFSVLTDVAE KSVQPLADED SKSKNQPSFQ WRQPSLDVEV GDPNPDVVSF RSTWVKRIQE NKQKWKERAA SGITNQMSID ELSPCEEEAP PSPAEDEHNQ NGN
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 93%.
Target Information
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 63 a Cam PDE; 63 a Cam-PDE; 63 kDa Cam-PDE; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; calmodulin-stimulated phosphodiesterase PDE1B1; Cam PDE 1B; Cam PDE1B; Cam-PDE 1B; Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; epididymis secretory sperm binding protein Li 79p; PDE 1B; PDES 1B; Phosphodiesterase; phosphodiesterase 1B, calmodulin-dependent; presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B; unnamed protein product
Gene Aliases: HEL-S-79p; PDE1B; PDE1B1; PDES1B
UniProt ID: (Human) Q01064
Entrez Gene ID: (Human) 5153
cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
protein binding
calmodulin binding
phosphoric diester hydrolase activity
hydrolase activity
metal ion binding
3',5'-cyclic-GMP phosphodiesterase activity
calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
response to amphetamine
signal transduction
locomotory behavior
visual learning
monocyte differentiation
cellular response to macrophage colony-stimulating factor stimulus
dopamine catabolic process
serotonin metabolic process
cellular response to granulocyte macrophage colony-stimulating factor stimulus
negative regulation of cAMP/PKA signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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