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Invitrogen
TCP-1 theta Polyclonal Antibody
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FIGURE: 1 / 8
TCP-1 theta Antibody (PA5-53830) in IHC
Immunohistochemical staining of TCP-1 theta in human cerebral cortex, lymph node, pancreas and testis using TCP-1 theta Polyclonal Antibody (Product # PA5-53830) (A) shows similar protein distribution across tissues to an independent TCP-1 theta Polyclonal Antibody (B).
Product Details
PA5-53830
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TCP-1 theta. Recombinant protein control fragment (Product #RP-91817).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LPNLVCCSAK NLRDIDEVSS LLRTSIMSKQ YGNEVFLAKL IAQACVSIFP DSGHFNVDNI RVCKILGSGI SSSSVLHGMV FKKETEGDVT
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 91%.
Target Information
TCP-1 theta is theta subunit of the CCT (chaperonin containing TCP1 complex) chaperonin molecule which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of the newly synthesized proteins. Molecular chaperones assist in the protein folding upon ATP hydrolysis and TCP-1 theta may play a role in the assembly of the BBsome, a complex that is involved in ciliogenesis regulating transport vesicles to the cilia. Further, TCP-1 theta is also involved in the folding of actin and tubulin. The intact CCT complex is composed of eight polypeptides in a double ring structure. CCT is important within cells in the folding of the VHL tumor suppressor protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CCT-theta; Chaperonin containing T-complex polypeptide 1 subunit 8; chaperonin containing TCP1, subunit 8 (theta); chaperonin subunit 8 (theta); Renal carcinoma antigen NY-REN-15; T-complex protein 1 subunit theta; TCP-1-theta
Gene Aliases: AI132397; C21orf112; CCT8; CCTQ; D21S246; KIAA0002; PRED71; Tcpq
UniProt ID: (Human) P50990, (Mouse) P42932
Entrez Gene ID: (Human) 10694, (Rat) 288305, (Mouse) 12469
protein folding
binding of sperm to zona pellucida
positive regulation of telomere maintenance via telomerase
pore complex assembly
protein stabilization
cell-cell adhesion
toxin transport
positive regulation of establishment of protein localization to telomere
positive regulation of protein localization to Cajal body
positive regulation of telomerase RNA localization to Cajal body
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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