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Invitrogen
FNTA Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-53858
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FNTA. Recombinant protein control fragment (Product #RP-101897).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LDSPSYVLYR HFRRVLLKSL QKDLHEEMNY ITAIIEEQPK NYQVWHHRRV LVEWLRDPSQ ELEFIADI
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 84%.
Target Information
FNTA (Farnesyltransferase, CAAX box; alphaCAAX farnesyltransferase alpha subunit, FPTA, FTase-alpha, GGTase-I-alpha, Protein farnesyl transferase/ geranyl geranyl transferase type I alpha subunit(PGGT1A), Ras proteins prenyl transferase alpha, Type I protein geranyl-geranyl transferase alpha subunit) is located locus 8p11 (human). Prenylation is a common intracellular posttranslational protein modification catalyzed by prenyltransferases. The best characterized among these prenyltransferases is the CAAX farnesyl transferase (2. 5. 1. 21), which is alpha-beta heterodimeric enzyme. It catalyzes the attachment of a farnesyl group from farnesyl phosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the CAAX box. FNTA or the alpha subunit of farnesyl transferase is shared by the geranyl-geranyl protein transferases. Apart from transfer of farnesyl and geranyl groups to proteins, FNTA has been proposed to regulate intracellular signaling pathways involving p21ras. Reports have shown that FNTA interacts with TGF-beta and activin-type I receptors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: farnesyl-protein transferase alpha-subunit; farnesyltransferase, CAAX box, alpha; FTase-alpha; GGTase-I-alpha; protein prenyltransferase alpha subunit repeat containing 2; ras proteins prenyltransferase subunit alpha; type I protein geranyl-geranyltransferase alpha subunit; unnamed protein product
Gene Aliases: FPTA; PGGT1A; PTAR2
UniProt ID: (Human) P49354
Entrez Gene ID: (Human) 2339
protein farnesyltransferase activity
protein geranylgeranyltransferase activity
CAAX-protein geranylgeranyltransferase activity
Rab geranylgeranyltransferase activity
protein binding
microtubule binding
protein prenyltransferase activity
acetyltransferase activator activity
enzyme binding
receptor tyrosine kinase binding
alpha-tubulin binding
binding, bridging
enzyme linked receptor protein signaling pathway
transforming growth factor beta receptor signaling pathway
peptide pheromone maturation
neuromuscular junction development
protein farnesylation
protein geranylgeranylation
positive regulation of Rac protein signal transduction
regulation of microtubule-based movement
skeletal muscle acetylcholine-gated channel clustering
CAAX-box protein maturation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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