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Invitrogen
AKAP13 Polyclonal Antibody
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Product Details
PA5-54078
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human AKAP13. Recombinant protein control fragment (Product #RP-102442).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ARELKEQLHQ KDQKILLLLE EKEMIFRDMA ECSTPLPEDC SPTHSPRVLF RSNTEEALKG GPLMKSAINE VEILQGLVSG NLGGTLGPTV SSPIEQDVVG PVSLPR
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 87%.
Target Information
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: A kinase (PRKA) anchor protein 13; A-kinase anchor protein 13; A-kinase anchoring protein; AKAP-13; AKAP-Lbc; Breast cancer nuclear receptor-binding auxiliary protein; Guanine nucleotide exchange factor Lbc; Human thyroid-anchoring protein 31; LBC oncogene; Lymphoid blast crisis oncogene; Non-oncogenic Rho GTPase-specific GTP exchange factor; p47; PRKA13; Protein kinase A-anchoring protein 13
Gene Aliases: AKAP-13; AKAP-Lbc; AKAP13; ARHGEF13; BRX; c-lbc; HA-3; HT31; LBC; p47; PRKA13; PROTO-LB; PROTO-LBC
UniProt ID: (Human) Q12802
Entrez Gene ID: (Human) 11214
protein phosphorylation
G-protein coupled receptor signaling pathway
heart development
regulation of cardiac muscle hypertrophy
positive regulation of Rho protein signal transduction
intracellular signal transduction
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of GTPase activity
regulation of protein kinase activity
regulation of small GTPase mediated signal transduction
nuclear export
cardiac muscle cell differentiation
regulation of sarcomere organization
bone development
adrenergic receptor signaling pathway
adrenergic receptor signaling pathway involved in heart process
regulation of glucocorticoid mediated signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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