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Invitrogen
PHIP Polyclonal Antibody
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Product Details
PA5-54093
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PHIP. Recombinant protein control fragment (Product #RP-92476).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TEQPSTSSAA KTFITKANAS AIPGKTILEN SVKHSKALNT LSSPGQSSFS HGTRNNSAKE NMEKEKPVKR KMKSSVLPKA STLSKSSA
Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 81%.
Target Information
PHIP (pleckstrin homology domain interacting protein), also known as ndrp or WDR11, is a 1,821 amino acid protein that contains eight N-terminal WD40 repeats and two bromodomains. It is expressed in skeletal muscle (localizing to the cytosol and nucleus) and primary beta cells (localizing to the nucleus) and acts as a transcriptional activator. PHIP is known to interact with various members of the insulin receptor substrate (IRS) family. The IRS family of proteins mediate insulin receptor signaling and play an important role in insulin-producing beta cell proliferation and survival. PHIP specifically associates with the PH domain of IRS-1 and may function to link IRS-1 to insulin receptors, indicating a vital role of PHIP in the regulation of insulin signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DDB1 and CUL4 associated factor 14; DDB1- and CUL4-associated factor 14; FLJ20705; IRS-1 PH domain-binding protein; PH-interacting protein; PHIP; WD repeat-containing protein 11
Gene Aliases: BRWD2; DCAF14; ndrp; PHIP; WDR11
UniProt ID: (Human) Q8WWQ0
Entrez Gene ID: (Human) 55023
regulation of protein phosphorylation
cytoskeleton organization
positive regulation of cell proliferation
insulin receptor signaling pathway
regulation of cell shape
regulation of cell morphogenesis
negative regulation of apoptotic process
positive regulation of insulin-like growth factor receptor signaling pathway
positive regulation of mitotic nuclear division
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of extrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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