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Invitrogen
CCDC155 Polyclonal Antibody
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FIGURE: 1 / 5
CCDC155 Antibody (PA5-54115) in IHC
Immunohistochemical staining of CCDC155 in human cerebral cortex, colon, lymph node and testis using CCDC155 Polyclonal Antibody (Product # PA5-54115) (A) shows similar protein distribution across tissues to an independent CCDC155 Polyclonal Antibody (B).
Product Details
PA5-54115
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CCDC155. Recombinant protein control fragment (Product #RP-91569).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EENGKLLAER DGVKKRSQEL AMEKDTLKRQ LFECEHLICQ RDTILSERTR DVESLAQTLE EYRVTTQELR LEISRLEEQL SQTYEGPDEL PEGA
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 81%.
Target Information
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homolog pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: coiled-coil domain containing 155; Coiled-coil domain-containing protein 155; KASH domain-containing protein 5; Protein KASH5; unnamed protein product
Gene Aliases: CCDC155; KASH5; POF22; SPGF88
UniProt ID: (Human) Q8N6L0
Entrez Gene ID: (Human) 147872
double-strand break repair via homologous recombination
actin filament organization
synapsis
spermatogenesis
telomere localization
meiotic telomere clustering
oogenesis
spindle assembly
meiotic cell cycle
spindle localization
chromosome localization to nuclear envelope involved in homologous chromosome segregation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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