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Invitrogen
AASS Polyclonal Antibody
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Product Details
PA5-54262
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human AASS. Recombinant protein control fragment (Product #RP-92606).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MLQVHRTGLG RLGVSLSKGL HHKAVLAVRR EDVNAWERRA PLAPKHIKGI TNLGYKVLIQ PSNRRAIHDK DYVKAGGILQ EDISEACLIL GVKRPPEEKL MSRKTYAFFS HTIKAQEANM GLLDEILKQE IR
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 84%.
Target Information
AASS is a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively, resulting in the conversion of lysine to alpha-aminoadipic semialdehyde. Mutations in the gene encoding this protein are associated with familial hyperlysinemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aass {ECO:0000312|EMBL:AAI28772.1}; alpha-aminoadipate semialdehyde synthase; Alpha-aminoadipic semialdehyde synthase, mitochondrial; aminoadipic semialdehyde synthase; bifunctional enzyme; LKR/SDH; lysine oxoglutarate reductase; lysine-2-oxoglutarate reductase; lysine-ketoglutarate reductase /saccharopine dehydrogenase; saccharopine dehydrogenase; saccharopine dehydrogenase (NAD(+), L-glutamate-forming); saccharopine dehydrogenase (NADP(+), L-lysine-forming); unnamed protein product
Gene Aliases: AASS; LKR; LKR/SDH; LKRSDH; LOR; LOR/SDH; LORSDH; SDH
UniProt ID: (Human) Q9UDR5, (Mouse) Q99K67, (Rat) A2VCW9
Entrez Gene ID: (Human) 10157, (Mouse) 30956, (Rat) 296925
transcription corepressor activity
catalytic activity
saccharopine dehydrogenase activity
saccharopine dehydrogenase (NAD+, L-lysine-forming) activity
oxidoreductase activity
histone binding
saccharopine dehydrogenase (NADP+, L-lysine-forming) activity
saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity
molecular_function
dehydrogenase
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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