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Invitrogen
SMARCC2 Polyclonal Antibody
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Product Details
PA5-54351
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SMARCC2. Recombinant protein control fragment (Product #
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Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: AFGLESSGIA GTTSDEPERI EESGNDEARV EGQATDEKKE PKEPREGGGA IEEEAKEKTS EAPKKDEEKG KEGDSEKESE KSDGDPIVDP EKEKEPKEGQ EEVLKEVVES EGERKTKVER DIGEGNLSTA A
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 88%.
Target Information
Cdc73 is a tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. Cdc73 is part of the PAF1 complex, a five-subunit protein complex composed of Paf1, Cdc73, Leo1, Rtf1 and Ctr9. PAF1 was first purified from yeast in association with RNA polymerase II and is believed to function in transcription elongation. The yeast PAF (yPAF) complex interacts with RNA polymerase II and coordinates the setting of histone marks associated with active transcription. In addition to coordinating events during transcription (initiation, promoter clearance, and elongation), hPAF also coordinates events in RNA quality control. Cdc73 may also be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BAF170; BRG1-associated factor 170; chromatin remodeling complex BAF170 subunit; DKFZp313D0632; mammalian chromatin remodeling complex BRG1-associated factor 170; SWI/SNF complex 170 kDa subunit; SWI/SNF complex subunit SMARCC2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2; SWI3-like protein
Gene Aliases: BAF170; CRACC2; Rsc8; SMARCC2
UniProt ID: (Human) Q8TAQ2
Entrez Gene ID: (Human) 6601
negative regulation of transcription from RNA polymerase II promoter
nucleosome disassembly
chromatin remodeling
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
covalent chromatin modification
regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
ATP-dependent chromatin remodeling
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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