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Invitrogen
PUS7 Polyclonal Antibody
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Product Details
PA5-54983
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PUS7. Recombinant protein control fragment (Product #RP-92628).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PGFDVIYPKH KIQEAYREML TADNLDIDNM RHKIRDYSLS GAYRKIIIRP QNVSWEVVAY DDPKIPLFNT DVDNLEGKTP PVFASEGKYR ALKMDFSLPP STYATMAIRE VLKMDTSIKN QTQ
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.
Target Information
Pseudouridylate synthase that catalyzes pseudouridylation of RNAs (PubMed:28073919, PubMed:29628141, PubMed:30778726). Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex (PubMed:29628141). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (PubMed:28073919). In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types (PubMed:29628141). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ20485; pseudouridylate synthase 7 (putative); Pseudouridylate synthase 7 homolog; unnamed protein product
Gene Aliases: C330017I15Rik; IDDABS; KIAA1897; PUS7; RGD1307054
UniProt ID: (Human) Q96PZ0, (Mouse) Q91VU7
Entrez Gene ID: (Human) 54517, (Rat) 296751, (Mouse) 78697
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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