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Invitrogen
NMU Polyclonal Antibody
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Product Details
PA5-55269
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Neuromedin U-8. Recombinant protein control fragment (Product #RP-88744).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ILPQGLQPEQ QLQLWNEIDD TCSSFLSIDS QPQASNALEE LCFMIMGMLP KPQEQDEKDN TKRFLFHYSK TQKLGKSNVV SSVVHPLLQL VPHLHERRMK RFRVDEEFQS PFASQSRGYF LFRPRNGRRS AGFI
Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 72%.
Target Information
This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: neuromedin U precursor-related peptide/neuromedin U preproprotein; Neuromedin-U; NmU 25; prepro-NMU
Gene Aliases: NMU
UniProt ID: (Human) P48645
Entrez Gene ID: (Human) 10874
temperature homeostasis
gastric acid secretion
positive regulation of systemic arterial blood pressure
regulation of smooth muscle contraction
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
photoperiodism
positive regulation of heart rate
positive regulation of heat generation
eating behavior
regulation of circadian sleep/wake cycle, sleep
positive regulation of smooth muscle contraction
positive regulation of hormone secretion
positive regulation of synaptic transmission
regulation of feeding behavior
negative regulation of gastric acid secretion
energy homeostasis
negative regulation of gastric emptying
positive regulation of stomach fundus smooth muscle contraction
positive regulation of prolactin secretion
negative regulation of eating behavior
positive regulation of sensory perception of pain
negative regulation of feeding behavior
regulation of grooming behavior
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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