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Invitrogen
ERRF Polyclonal Antibody
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Product Details
PA5-55373
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ERRF. Recombinant protein control fragment (Product #RP-92440).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: HLTRVTPMGG GCLAQARATL PLCRGSVASA SFPVSPLCPQ EVPEAKGKPV KAAPVRSSTW GTVKDSLKAL SSCVCGQ
Highest antigen sequence identity to the following orthologs: Mouse - 42%, Rat - 30%.
Target Information
The estrogen receptor-related factor (ERRF) is a recently identified protein whose expression is upregulated in multiple cell lines and primary breast cancer tumors. Increased ERRF expression was significantly associated with ER or progesterone receptor (PR) positivity even in HER2-negative tumors. This higher ERRF expression correlated with better disease-free survival and overall survival. In two ER-positive breast cancer cell lines, knockdown of ERRF suppressed cell growth in vitro and tumorigenesis in xenograft models, suggesting that ERRF plays a role in estrogen-ER-mediated breast cancer cell growth and may thus be a potential therapeutic target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ER-related factor; Estrogen receptor-related factor; RP11-5P18.4; Steroid receptor-associated and regulated protein; Steroid receptor-regulated protein
Gene Aliases: C1orf64; ERRF; SRARP; SSPR
UniProt ID: (Human) Q8NEQ6
Entrez Gene ID: (Human) 149563
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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