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Invitrogen
BNIP2 Polyclonal Antibody
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Product Details
PA5-55438
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human BNIP2. Recombinant protein control fragment (Product #RP-90795).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VELKEEWQDE DFPIPLPEDD SIEADILAIT GPEDQPGSLE VNGNKVRKKL MAPDISLTLD PSDGSVLSDD LDESGEIDLD GLDTPSENSN EFEWEDDLPK PKTTEVIRKG SITEYTAAEE KEDGRRWRMF RIGEQDHRV
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.
Target Information
BNIP-2, (previously designated Nip2 and Nip21 in human and mouse respectively), shares homology with the non-catalytic domain of Cdc42 GTPase-activating protein (Cdc42GAP). Through binding to Cdc42GAP, BNIP-2 enhances the GTPase activity of Cdc42GAP, facilitating the hydrolysis of GTP bound to Cdc42 and thereby, mediating the signaling pathways involving receptor kinases, small GTPases and apoptotic proteins. Nix, which is also designated Nip3L or Bnip3L, is highly related to BNIP-3, and both proteins localize to the mitochondria where they associate with Bcl-2 proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bcl-2 and E1B 19 kDa interacting protein; BCL2/adenovirus E1B 19 kDa protein-interacting protein 2; BCL2/adenovirus E1B 19kDa interacting protein 2; BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP2; BNIP 2; BNIP2; unnamed protein product
Gene Aliases: BNIP-2; BNIP2; NIP2
UniProt ID: (Human) Q12982
Entrez Gene ID: (Human) 663, (Rat) 300811
blastocyst development
apoptotic process
biological_process
positive regulation of MAPK cascade
positive regulation of neuron differentiation
positive regulation of small GTPase mediated signal transduction
striated muscle cell differentiation
centrosome organization
centrosome cycle
negative regulation of apoptotic process
response to oxygen-glucose deprivation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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