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Invitrogen

SCP2 Polyclonal Antibody

View all (12) SCP2 antibodies

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SCP2 Polyclonal Antibody

Product Details

PA5-55519

Applications
Tested Dilution
Publications

Western Blot (WB)

0.04-0.4 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SCP2. Recombinant protein control fragment (Product #RP-94062).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Amount

10 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2647025

Product Specific Information

Immunogen sequence: GKKALADAQI PYSAVDQACV GYVFGDSTCG QRAIYHSLGM TGIPIINVNN NCATGSTALF MARQLIQGGV AECVLALGFE KMSKGSLGIK FSDRTIPTDK H

Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 83%.

Target Information

This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: acetyl-CoA C-myristoyltransferase; epididymis secretory sperm binding protein; non-specific lipid-transfer protein; nonspecific lipid transfer protein; NSL-TP; propanoyl-CoA C-acyltransferase; SCP-2; SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; SCP-chi; SCP-X; Sterol carrier protein 2, liver; sterol carrier protein X; sterol carrier protein-2 (SCP-2); straight-chain acyl-CoA oxidase; unnamed protein product

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Gene Aliases: NLTP; ns-LTP; NSL-TP; NSLIPTR; nsLTP; SCOX; SCP-2; SCP-CHI; SCP-X; SCPX

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UniProt ID: (Human) P22307, (Mouse) P32020, (Rat) P11915

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Entrez Gene ID: (Human) 6342, (Mouse) 20280, (Rat) 25541

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Function(s)
fatty-acyl-CoA binding acetyl-CoA C-acyltransferase activity receptor binding fatty acid binding protein binding phosphatidylinositol transporter activity cholesterol binding transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups propanoyl-CoA C-acyltransferase activity long-chain fatty acyl-CoA binding propionyl-CoA C2-trimethyltridecanoyltransferase activity acetyl-CoA C-myristoyltransferase activity oleic acid binding phosphatidylcholine transfer activity intermembrane cholesterol transfer activity identical protein binding macromolecular complex binding phosphatidylethanolamine transporter activity
Process(es)
fatty acid biosynthetic process fatty acid beta-oxidation steroid biosynthetic process bile acid biosynthetic process progesterone biosynthetic process bile acid metabolic process phospholipid transport sterol transport regulation of lipid metabolic process fatty acid oxidation intracellular cholesterol transport positive regulation of intracellular cholesterol transport inositol trisphosphate biosynthetic process fatty acid beta-oxidation using acyl-CoA oxidase alpha-linolenic acid metabolic process positive regulation of steroid metabolic process regulation of phospholipid biosynthetic process protein localization to plasma membrane intermembrane lipid transfer lipid hydroperoxide transport long-chain fatty acid metabolic process glycerol metabolic process lipid metabolic process fatty acid metabolic process acylglycerol metabolic process triglyceride metabolic process phospholipid metabolic process cholesterol metabolic process gene expression positive regulation of steroid biosynthetic process diterpenoid metabolic process arachidonic acid metabolic process triglyceride biosynthetic process cholesterol efflux multicellular organism growth lipoprotein metabolic process positive regulation of apoptotic process positive regulation of cholesterol biosynthetic process regulation of lipid biosynthetic process endocannabinoid signaling pathway positive regulation of cholesterol import response to estradiol response to luteinizing hormone cellular response to cholesterol
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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