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Invitrogen
SCP2 Polyclonal Antibody
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Product Details
PA5-55519
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SCP2. Recombinant protein control fragment (Product #RP-94062).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GKKALADAQI PYSAVDQACV GYVFGDSTCG QRAIYHSLGM TGIPIINVNN NCATGSTALF MARQLIQGGV AECVLALGFE KMSKGSLGIK FSDRTIPTDK H
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 83%.
Target Information
This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acetyl-CoA C-myristoyltransferase; epididymis secretory sperm binding protein; Non-specific lipid-transfer protein; nonspecific lipid transfer protein; NSL-TP; Propanoyl-CoA C-acyltransferase; SCP-2; SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; SCP-chi; SCP-X; SCPX; Sterol carrier protein 2; Sterol carrier protein 2, liver; Sterol carrier protein X; straight-chain acyl-CoA oxidase; unnamed protein product
Gene Aliases: AA409774; AA409893; C76618; C79031; NLTP; ns-LTP; NSL-TP; NSLIPTR; SCOX; SCP-2; SCP-CHI; SCP-X; SCP2; SCPX
UniProt ID: (Human) P22307, (Rat) P11915, (Mouse) P32020
Entrez Gene ID: (Human) 6342, (Rat) 25541, (Mouse) 20280
fatty-acyl-CoA binding
acetyl-CoA C-acyltransferase activity
receptor binding
protein binding
lipid binding
phosphatidylinositol transporter activity
cholesterol binding
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring acyl groups other than amino-acyl groups
propanoyl-CoA C-acyltransferase activity
long-chain fatty acyl-CoA binding
propionyl-CoA C2-trimethyltridecanoyltransferase activity
acetyl-CoA C-myristoyltransferase activity
oleic acid binding
phosphatidylcholine transfer activity
intermembrane cholesterol transfer activity
collagen binding
catalytic activity
phosphatidylcholine transporter activity
cholesterol transporter activity
protein homodimerization activity
protein heterodimerization activity
phosphatidylethanolamine transporter activity
acyltransferase
transfer/carrier protein
lipid metabolic process
fatty acid beta-oxidation
unsaturated fatty acid biosynthetic process
steroid biosynthetic process
bile acid biosynthetic process
progesterone biosynthetic process
lipid transport
bile acid metabolic process
phospholipid transport
sterol transport
regulation of lipid metabolic process
intracellular cholesterol transport
positive regulation of intracellular cholesterol transport
inositol trisphosphate biosynthetic process
fatty acid beta-oxidation using acyl-CoA oxidase
alpha-linolenic acid metabolic process
long-chain fatty acid biosynthetic process
positive regulation of steroid metabolic process
regulation of phospholipid biosynthetic process
protein localization to plasma membrane
intermembrane lipid transfer
lipid hydroperoxide transport
fatty acid derivative biosynthetic process
peroxisome organization
metabolic process
negative regulation of cell proliferation
positive regulation of steroid biosynthetic process
negative regulation of cell migration
acyl-CoA metabolic process
transport
aging
cholesterol transport
positive regulation of apoptotic process
positive regulation of cholesterol biosynthetic process
positive regulation of cholesterol import
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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