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Invitrogen
CDCA8 Polyclonal Antibody
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Product Details
PA5-55771
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CDCA8. Recombinant protein control fragment (Product #RP-94215).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PLKSAKTRKV IQVDEMIVEE EEEEENERKN LQTARVKRCP PSKKRTQSIQ GKGKGKRSSR ANTVTPAVGR LEVSMVKPTP GLTPRFDSR
Highest antigen sequence identity to the following orthologs: Mouse - 64%, Rat - 66%.
Target Information
CDCA8 is a component of a chromosomal passenger complex (CPC) required for stability of the bipolar mitotic spindle. The chromosomal passenger complex, which includes Survivin, CDCA8, INCENP and Aurora-B, is known to play crucial roles during mitosis and cell division. It was found that CDCA8 interacting with Aurora-B, INCENP and Survivin, increases during G2/M phase and then reduces after exit from M phase. CDCA8 is cell cycle regulated, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. In Drosophila cells, inactivation of CDCA8 results in polyploidy, delayed mitosis and abnormal tissue development, indicating its critical role for cell proliferation. Recent studies show that CDCA8 is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53. Its aberrant expression is linked to a poor prognosis for gastric cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Borealin; Cell division cycle-associated protein 8; Dasra B; Dasra-B; hDasra-B; HPESCRG3; Pluripotent embryonic stem cell-related gene 3 protein; unnamed protein product
Gene Aliases: BOR; BOREALIN; CDCA8; DasraB; MESRGP; PESCRG3
UniProt ID: (Human) Q53HL2
Entrez Gene ID: (Human) 55143
mitotic sister chromatid segregation
mitotic cell cycle
mitotic cytokinesis
mitotic metaphase plate congression
mitotic spindle midzone assembly
chromosome organization
cell division
positive regulation of mitotic cell cycle spindle assembly checkpoint
mitotic spindle assembly
positive regulation of mitotic sister chromatid separation
positive regulation of attachment of mitotic spindle microtubules to kinetochore
positive regulation of mitotic cytokinesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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