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Invitrogen
SLC12A3 Polyclonal Antibody
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Product Details
PA5-55969
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SLC12A3. Recombinant protein control fragment (Product #RP-102376).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LLIPYLLGRK RRWSKCKIRV FVGGQINRMD QERKAIISLL SKFRLGFHEV HILPDINQNP RAEHTKRFED MIAPFRLNDG FKDEATVNEM RRDCPWKISD EEITKNRVKS LRQVRLNEIV LDYSRDAALI VITLPIGRKG KCPSS
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 90%.
Target Information
The SLC12A3 gene encodes the thiazide-sensitive sodium-chloride symporter (NCC), which is critical for salt balance and blood pressure regulation in humans. This symporter is predominantly expressed in the distal convoluted tubule of the kidney, where it facilitates the reabsorption of sodium and chloride ions from the renal filtrate back into the bloodstream. NCC activity plays a vital role in maintaining extracellular fluid volume and potassium homeostasis, impacting systemic blood pressure. Mutations in SLC12A3 can lead to Gitelman syndrome, a hereditary salt-wasting disorder characterized by hypokalemic metabolic alkalosis, low blood pressure, and hypomagnesemia. This gene is regulated by the renin-angiotensin system, which modulates NCC activity through phosphorylation mediated by WNK kinases, thereby affecting renal sodium handling and blood pressure modulation. Research highlights the therapeutic potential of targeting NCC with thiazide diuretics to treat hypertension, emphasizing its importance in both physiological and pathological contexts. The dynamic regulation of NCC by hormonal pathways underscores its significance in fluid and electrolyte balance, contributing to cardiovascular health.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: chemokine (C-C); CK-beta-10; CKb10; MCP-4; MGC17134; Na-Cl cotransporter; Na-Cl symporter; NaCl electroneutral thiazide-sensitive cotransporter; NCC; NCC-1; NCC1; SCYA13; SCYL1; sodium-chloride co-transporter; solute carrier family 12 (sodium/chloride transporter), member 3; Solute carrier family 12 member 3; thiazide-sensitive Na-Cl cotransporter; Thiazide-sensitive sodium-chloride cotransporter
Gene Aliases: NCC; NCCT; SLC12A3; TSC
UniProt ID: (Human) P55017
Entrez Gene ID: (Human) 6559
ion transport
sodium ion transport
cell volume homeostasis
sodium ion transmembrane transport
chloride ion homeostasis
potassium ion homeostasis
sodium ion homeostasis
transmembrane transport
renal sodium ion absorption
response to salt
chloride transmembrane transport
response to aldosterone
potassium ion import across plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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