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Product Details
PA5-56292
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Plectin. Recombinant protein control fragment (Product #RP-93970).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TEIIRQQGLA SYDYVRRRLT AEDLFEARII SLETYNLLRE GTRSLREALE AESAWCYLYG TGSVAGVYLP GSRQTLSIYQ ALKKGLLSAE VARLLLEAQA A
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 92%.
Target Information
Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes. Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans. The expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development and it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms which carry out distinct and specific functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HD1; Hemidesmosomal protein 1; PCN; PLEC1a; PLEC1b; Plectin; plectin 1, intermediate filament binding protein 500kDa; Plectin-1
Gene Aliases: EBS1; EBS5A; EBS5B; EBS5C; EBS5D; EBSMD; EBSND; EBSO; EBSOG; EBSPA; HD1; LGMD2Q; LGMDR17; PCN; PLEC; PLEC1; PLEC1b; PLTN
UniProt ID: (Human) Q15149
Entrez Gene ID: (Human) 5339
cell morphogenesis
leukocyte migration involved in immune response
keratinocyte development
nucleus organization
mitochondrion organization
actin filament organization
skeletal muscle tissue development
protein localization
gene expression
fibroblast migration
T cell chemotaxis
skeletal myofibril assembly
transmission of nerve impulse
myelination in peripheral nervous system
respiratory electron transport chain
actin cytoskeleton organization
keratinocyte differentiation
hemidesmosome assembly
response to food
peripheral nervous system myelin maintenance
adherens junction organization
multicellular organism growth
wound healing
regulation of vascular permeability
skin development
protein-containing complex subunit organization
intermediate filament cytoskeleton organization
intermediate filament organization
sarcomere organization
myoblast differentiation
skeletal muscle fiber development
cell motility
cardiac muscle cell development
establishment of skin barrier
cellular response to mechanical stimulus
cellular response to hydrostatic pressure
cellular response to fluid shear stress
tight junction organization
actomyosin contractile ring assembly actin filament organization
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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