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Invitrogen
RUSC1 Polyclonal Antibody
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Product Details
PA5-56298
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RUSC1. Recombinant protein control fragment (Product #RP-94358).
Conjugate
Form
Liquid
Concentration
0.9 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QAMLHFGGRL AQSLRGTSKE AASDPSDSPN LPTPGSWWEQ LTQASRVYAS GGTEGFPLSR WAPGRHGTAA EEGAQERPLP TDEMAPGRGL WLGRLFGVP
Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 71%.
Target Information
RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC1 is an adapter protein that can bind to the TrkA receptor and is necessary in the NGF-induced neurite growth of PC12 cells. RUSC1 has also been shown to interact with Ikappa-B kinase- (IKK-) -gamma, the regulatory subunit of the IKK complex that is required for NF-kappa-B activation in many signaling pathways such as TNF-R or the TLR pathways. RUSC1 can also bind to the E3 ubiquitin ligase TRAF6, which then catalyzes RUSC1 polyubiquitination. Since overexpression of RUSC1 strongly inhibits TRAF6-mediated polyubiquitination of IKK-gamma, RUSC1 may be a link in the IKK-gamma-mediated NF-kappa-B activation pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AP-4 complex accessory subunit RUSC1; Nesca; New molecule containing SH3 at the carboxy-terminus; RP11-21N7.4; RUN and SH3 domain-containing protein 1
Gene Aliases: NESCA; RUSC1
UniProt ID: (Human) Q9BVN2
Entrez Gene ID: (Human) 23623
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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