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Invitrogen
FRS3 Polyclonal Antibody
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Product Details
PA5-56385
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FRS3. Recombinant protein control fragment (Product #RP-94865).
Conjugate
Form
Liquid
Concentration
0.7 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GAGWRLSPEE PGWNGLAHRR AALLHYENLP PLPPVWESQA QQLGGEAGDD GDSRDGLTPS SNGFPDGEED ETPLQKPTST RAAIRSHGSF PVPLT
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 93%.
Target Information
FRS3 (fibroblast growth factor receptor substrate 3), also known as FRS2B (FRS2-beta), is a 492 amino acid lipid-anchor adapter protein that contains one IRS-type PTB domain. Colocalizing to neural tissues with Tuj1, FRS3 functions as a feedback inhibitor of EGFR family members by preventing heterodimer formation between EGFR and ErbB2, thereby acting as a potential tumor suppressor. FRS3 is phosphorylated upon stimulation by FGF-2 or NGF and, acting as an adapter protein, links c-Fgr and NGF receptors to downstream signaling pathways. Interfering with the phosphorylation and nuclear translocation of ERK-2, FRS3 down-regulates ERK-2 expression. FRS3 likely interacts directly with GRB2, SH-PTP2, Flg, and Trk A, and may be involved in MAP kinase activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FGFR substrate 3; FGFR-signaling adaptor SNT2; Fibroblast growth factor receptor substrate 3; FRS3; SNT-2; Suc1-associated neurotrophic factor target 2; suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor); testicular tissue protein Li 71
Gene Aliases: FRS2-beta; FRS2B; FRS2beta; FRS3; SNT-2; SNT2
UniProt ID: (Human) O43559, (Rat) Q52RG8
Entrez Gene ID: (Human) 10817, (Rat) 316213
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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