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Invitrogen
VMP1 Polyclonal Antibody
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Product Details
PA5-56555
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human VMP1. Recombinant protein control fragment (Product #RP-102047).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LYLGPHIASV TLAAYECNSV NFPEPPYPDQ IICPDEEGTE GTISLWSIIS KVRIEACMWG IGTAIGELPP YFMARAARLS GAEPDDEEYQ EFEEMLEHAE
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 99%.
Target Information
VMP1 is a stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis.VMP1 is a transmembrane protein that co-localizes with LC3, a marker of the autophagosomes. It interacts with beclin-1, a mammalian autophagy initiator, through the VMP1-Atg domain, which is essential for autophagosome formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ectopic P-granules autophagy protein 3 homolog; Transmembrane protein 49; transport and golgi organization 5 homolog; unnamed protein product; Vacuole membrane protein 1; VMP1
Gene Aliases: EPG3; HSPC292; TANGO5; TDC1; TMEM49; VMP1
UniProt ID: (Human) Q96GC9
Entrez Gene ID: (Human) 81671
autophagosome assembly
lipid transport
autophagy
Golgi organization
cell adhesion
embryo implantation
autophagosome membrane docking
phospholipid scrambling
cell junction assembly
lipoprotein transport
cell-cell adhesion
organelle localization by membrane tethering
positive regulation of calcium-transporting ATPase activity
mitochondrion-ER tethering
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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