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Invitrogen
MCM9 Polyclonal Antibody
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Product Details
PA5-56653
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MCM9. Recombinant protein control fragment (Product #RP-94959).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SPPPERKNRG ERGPSSPPTT TAPMRVSKRK SFQLRGSTEK LIVSKESLFT LPELGDEAFD CDWD
Highest antigen sequence identity to the following orthologs: Mouse - 47%, Rat - 53%.
Target Information
Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8- MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA 3'-5' helicase MCM9; DNA helicase MCM9; DNA replication licensing factor MCM9; hMCM9; Mini-chromosome maintenance deficient domain-containing protein 1; Minichromosome maintenance 9; minichromosome maintenance complex component 9; unnamed protein product
Gene Aliases: C6orf61; dJ329L24.1; dJ329L24.3; MCM9; MCMDC1; ODG4
UniProt ID: (Human) Q9NXL9
Entrez Gene ID: (Human) 254394
nucleotide binding
DNA binding
DNA helicase activity
chromatin binding
single-stranded DNA binding
helicase activity
protein binding
ATP binding
hydrolase activity
ATPase activity
single-stranded DNA-dependent ATP-dependent DNA helicase activity
enzyme binding
MutLbeta complex binding
MutSalpha complex binding
MutSbeta complex binding
macromolecular complex binding
double-strand break repair via homologous recombination
DNA replication
DNA repair
cellular response to DNA damage stimulus
gamete generation
female gamete generation
recombinational interstrand cross-link repair
mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication
protein localization to chromatin
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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