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Invitrogen
NALCN Polyclonal Antibody
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Product Details
PA5-56888
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NALCN. Recombinant protein control fragment (Product #RP-95696).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QDNSMQPETS SQQQLLSPTL SDRGGSRQDA ADAGKPQRKF GQWRLPSAPK PISHSVSSVN LRFGGRTTMK SVVCKMNPMT DAASCGSEVK KWWT
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 91%.
Target Information
Nalcn is a voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Nalcn regulates the resting membrane potential and controls neuronal excitability (PubMed:17448995). Neuropeptides such as neurotensin and substance P (SP) stimulate the firing of action potentials by activating NALCN through a SRC family kinases-dependent pathway. In addition to its baseline activity, Nalcn activity is enhanced/modulated by several GPCRs, is required for normal respiratory rhythm and neonatal survival, is involved in systemic osmoregulation by controlling the serum sodium concentration. Nalcn is partly responsible for the substance P-induced depolarization and regulation of the intestinal pace-making activity in the interstitial cells of Cajal. Further, Nalcn plays a critical role in both maintenance of spontaneous firing of substantia nigra pars reticulata (SNr) neurons and physiological modulation of SNr neuron excitability. Diseases associated with NALCN include Congenital contractures of the limbs and face, Hypotonia, Developmental Delay and Hypotonia, Infantile Psychomotor Retardation And Characteristic Facies 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CanIon; FLJ23913; FLJ44659; FLJ44764; four repeat voltage-gated ion channel; MGC74524; Sodium leak channel NALCN; Sodium leak channel non-selective protein; unnamed protein product; voltage gated channel like 1; Voltage gated channel-like protein 1
Gene Aliases: bA430M15.1; CanIon; CLIFAHDD; IHPRF; IHPRF1; INNFD; NALCN; VGCNL1
UniProt ID: (Human) Q8IZF0
Entrez Gene ID: (Human) 259232
ion transport
sodium ion transport
positive regulation of synaptic transmission, cholinergic
positive regulation of synaptic transmission, GABAergic
ion transmembrane transport
sodium ion transmembrane transport
transmembrane transport
regulation of resting membrane potential
calcium ion transmembrane transport
potassium ion transmembrane transport
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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