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Invitrogen
PEX13 Polyclonal Antibody
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Product Details
PA5-56942
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PEX13. Recombinant protein control fragment (Product #RP-95803).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SADLGPTLMT RPGQPALTRV PPPILPRPSQ QTGSSSVNTF RPAYSSFSSG YGAYGNSFYG GYSPYSYGYN GLGYNRLRVD DLPPSRFVQQ AEESSRGA
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 92%.
Target Information
PEX13 (Peroxisomal Biogenesis Factor 13) is a gene located on chromosome 2p15 that encodes a peroxisomal membrane protein essential for the biogenesis and function of peroxisomes, which are cellular organelles involved in lipid metabolism and detoxification of reactive oxygen species. PEX13 is a component of the peroxisomal import machinery that specifically recognizes and binds to peroxisomal targeting signal 1 (PTS1) containing proteins, facilitating their import into the peroxisome matrix. Mutations in the PEX13 gene can lead to Zellweger spectrum disorders, a group of peroxisome biogenesis disorders (PBDs) characterized by defects in multiple peroxisomal metabolic pathways, leading to severe developmental issues, neurological deficits, and often early lethality. Studies of PEX13 have helped elucidate the mechanisms of peroxisomal protein import and the broader implications of peroxisomal dysfunction in human disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Peroxin-13; Peroxisomal membrane protein PEX13
Gene Aliases: NALD; PBD11A; PBD11B; PEX13; ZWS
UniProt ID: (Human) Q92968
Entrez Gene ID: (Human) 5194
fatty acid alpha-oxidation
neuron migration
suckling behavior
positive regulation of defense response to virus by host
locomotory behavior
protein import into peroxisome matrix, docking
cerebral cortex cell migration
microtubule-based peroxisome localization
mitophagy in response to mitochondrial depolarization
xenophagy
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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