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Invitrogen
DGUOK Polyclonal Antibody
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FIGURE: 1 / 1
DGUOK Antibody (PA5-57051) in WB
Western blot analysis of DGUOK in control (vector only transfected HEK293T lysate) and DGUOK over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells). Samples were probed using a DGUOK Polyclonal Antibody (Product # PA5-57051).
Product Details
PA5-57051
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DGUOK. Recombinant protein control fragment (Product #RP-95995).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: STFVKLLTKT YPEWHVATEP VATWQNIQAA GTQKACTAQS LGNLLDMMYR EPARWSYTFQ TFSFLSRLKV QLEPFPEKLL QARKPVQI
Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 77%.
Target Information
Mitochondrial deoxyguanosine kinase (DGUOK) is required for the phosphorylation of several deoxyribonucleosides and certain purine deoxykribonucleoside analogs widely employed as antiviral and chemotherapeutic agents. Purine deoxyribonucleoside analogs are extensively used in treatment of lymphoproliferative disorders. These compounds are administered as pro-drugs, and their efficiency is dependent on intracellular phosphorylation to the corresponding triphosphates. In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by 2 deoxyribonucleoside kinases: cytosolic deoxycytidine kinase (DCK) and mitochondrial deoxyguanosine kinase (DGUOK also known as DGK). DGUOK expression is ubiquitous, with highest levels in muscle, brain, liver and lymphoid tissues. Defects in DGUOK are a cause of mitochondrial DNA depletion syndrome (MDS). MDS is a clinically heterogeneous group of disorders characterized by a reduction in mitochondrial DNA (mtDNA) copy number. Primary mtDNA depletion is inherited as an autosomal recessive trait and may affect single organs, typically muscle or liver, or multiple tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Deoxyadenosine kinase, mitochondrial; Deoxyguanosine kinase, mitochondrial
Gene Aliases: DGK; DGUOK; MTDPS3; NCPH; NCPH1; PEOB4
UniProt ID: (Human) Q16854
Entrez Gene ID: (Human) 1716
nucleobase-containing compound metabolic process
guanosine metabolic process
negative regulation of neuron projection development
mitochondrial ATP synthesis coupled electron transport
dGTP metabolic process
purine deoxyribonucleoside metabolic process
dAMP salvage
carbohydrate derivative metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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