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Invitrogen
ZC3H8 Polyclonal Antibody
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Product Details
PA5-57065
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ZC3H8. Recombinant protein control fragment (Product #RP-96118).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: NLKAGHKNGK QKKMKRKWPG PGNKGSNALL RNSGSQEEDG KPKEKQQHLS QAFINQHT
Highest antigen sequence identity to the following orthologs: Mouse - 67%, Rat - 63%.
Target Information
Zinc-finger CCCH domain-containing protein 8 (ZC3H8) acts as a transcriptional repressor of the GATA3 promoter. It is a sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene. ZC3H8 induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Zinc finger CCCH domain-containing protein 8; zinc finger CCCH type domain containing 8; zinc finger CCCH-type domain containing 8
Gene Aliases: Fliz1; ZC3H8; ZC3HDC8
UniProt ID: (Human) Q8N5P1
Entrez Gene ID: (Human) 84524
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
poly(A) RNA binding
metal ion binding
zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
apoptotic process
negative regulation of T cell differentiation in thymus
snRNA transcription from RNA polymerase II promoter
snRNA transcription from RNA polymerase III promoter
T cell homeostasis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase III promoter
response to antibiotic
positive regulation of thymocyte apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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