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Invitrogen
RNF186 Polyclonal Antibody
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Product Details
PA5-57315
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RNF186. Recombinant protein control fragment (Product #RP-102671).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MACTKTLQQS QPISAGATTT TTAVAPAGGH SGSTECDLEC LVCREPYSCP
Highest antigen sequence identity to the following orthologs: Mouse - 58%, Rat - 58%.
Target Information
The RNF186 gene encodes the RING finger protein 186, a member of the RING-type E3 ubiquitin ligase family. RNF186 is involved in the ubiquitin-proteasome pathway, playing a crucial role in tagging target proteins for degradation, thus influencing protein turnover and cellular homeostasis. This process is essential for regulating various cellular functions, including signal transduction, apoptosis, and response to stress. RNF186 has been implicated in the unfolded protein response (UPR) within the endoplasmic reticulum, where it helps in managing protein folding and maintaining cellular homeostasis, particularly under conditions of endoplasmic reticulum stress. Alterations in RNF186 expression or function have been associated with disorders such as inflammatory bowel disease and ulcerative colitis, suggesting its role in gastrointestinal health and disease. Research into RNF186 focuses on its regulatory mechanisms within the ubiquitin-proteasome system and its potential as a therapeutic target for conditions associated with protein misfolding and cellular stress responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase RNF186; FLJ20225; RING finger protein 186; unnamed protein product
Gene Aliases: RNF186
UniProt ID: (Human) Q9NXI6
Entrez Gene ID: (Human) 54546
protein ubiquitination
protein K29-linked ubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein K63-linked ubiquitination
protein localization to mitochondrion
apoptotic process in response to mitochondrial fragmentation
regulation of autophagosome assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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