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Invitrogen
HOXA11 Polyclonal Antibody
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Product Details
PA5-57341
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Cat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human HOXA11. Recombinant protein control fragment (Product #RP-96536).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EVTFREYAIE PATKWHPRGN LAHCYSAEEL VHRDCLQAPS AAGVPGDVLA KSSANVYHHP TPAVSSNFY
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t (10:14) (q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: homeo box 1I; Homeobox protein Hox-1I; Homeobox protein Hox-A11; homeobox protein HOXA11; HOX11
Gene Aliases: HOX1; HOX1I; HOXA11; RUSAT1
UniProt ID: (Human) P31270
Entrez Gene ID: (Human) 3207
skeletal system development
metanephros development
branching involved in ureteric bud morphogenesis
organ induction
transcription, DNA-templated
multicellular organism development
spermatogenesis
single fertilization
mesodermal cell fate specification
male gonad development
anatomical structure morphogenesis
anterior/posterior pattern specification
dorsal/ventral pattern formation
proximal/distal pattern formation
positive regulation of cell development
embryonic limb morphogenesis
positive regulation of chondrocyte differentiation
embryonic forelimb morphogenesis
embryonic digit morphogenesis
positive regulation of transcription, DNA-templated
developmental growth
uterus development
embryonic skeletal joint morphogenesis
cartilage development involved in endochondral bone morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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