Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
RPUSD3 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
PA5-58001
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RPUSD3. Recombinant protein control fragment (Product #RP-96384).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VVDRKGPLVT LNKPQGLPVT GKPGELTLFS VLPELSQSLG LREQELQVVR ASGKESSGLV LLSSCPQTAS RLQKYFTHAR R
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 60%.
Target Information
RNA Pseudouridine Synthase D3 (RPUSD3) is a gene that encodes a pseudouridine synthase, an enzyme responsible for catalyzing the isomerization of uridine to pseudouridine in RNA molecules. This post-transcriptional modification is crucial for the stability and function of tRNAs and rRNAs. RPUSD3, along with other pseudouridine synthases such as PUS1, PUSL1, and TRUB2, is predicted to localize to mitochondria, indicating its role in mitochondrial RNA processing and maturation. The pseudouridylation activity provided by RPUSD3 is essential for the proper folding and functionality of mitochondrial RNAs, which are fundamental for the biogenesis of the mitochondrial electron transport chain and ATP synthase. While detailed structural insights into RPUSD3 are not yet fully characterized, its enzymatic function is critical in maintaining cellular energy metabolism and overall mitochondrial health.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Mitochondrial mRNA pseudouridine synthase RPUSD3; RNA pseudouridylate synthase domain-containing protein 3
Gene Aliases: AI527266; RGD1307582; RPUSD3
UniProt ID: (Human) Q6P087, (Mouse) Q14AI6
Entrez Gene ID: (Human) 285367, (Rat) 362416, (Mouse) 101122
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support